Transcripts exhibiting significant under expression in trisomic BG01V APCs and CCF-STTG1 astrocytoma cells relative to diploid H9 APCs include several markers of normal differentiated astrocytes, including TRPA1, GABRA2, BDNF, BDKRB1 and BDKRB2 [22-24]. The gene discussed is BDKRB1; the disease is astrocytoma (excluding glioblastoma).