DES and gastrointestinal stromal tumor: However, in cases where there is diagnostic difficulty particularly, when differentiating mesenteric lipodystrophy from gastrointestinal stromal tumours.(GISTs) and mesenteric fibromatosis, Montgomery et al. suggest that immunohistochemistry using a panel of antibodies (CD117, beta-catenin, CD34, smooth muscle actin, desmin, keratin, and S-100 protein) may help differentiate the histological types [15].