TP53 and cancer: The master regulator and tumor suppressor p53, which is one of the most important and studied proteins in the cancer field, is a tetrameric (dimer of dimer proteins) sequence-specific transcription factor able to bind to two copies of a decameric sequence with the RRRCWWGYYY consensus (where R stands for a purine, W for A/T and Y for a pyrimidine) [19].