A study of Type II iodothyronine deiodinase (DIO2) and ADRB3 polymorphisms showed a synergistic effect on an increased BMI, suggesting an interaction between these two common gene variants [69], while a study of intestinal fatty acid binding protein 2 (FABP2) and ADRB3 showed no interaction on levels of fasting plasma glucose or measures of insulin resistance [70]. The gene discussed is DIO2; the disease is Insulin resistance.