STAT3 and neoplasm: Upon activation by a wide variety of cell surface receptors, tyrosine phosphorylated Stat3 dimerizes and translocates to the nucleus and modulates the expression of target genes that are involved in various physiological functions including apoptosis (e.g., Survivin and Bcl-xL), cell cycle regulation (e.g., Cyclin D1, and c-Myc), and tumor angiogenesis (e.g., VEGF) [3], [5].