To examine the tumor suppressor role of Cdh11 in retinoblastoma development, we crossed Cdh11-/- mice with TAg-RB mice and analyzed genotypes Cdh11+/+;TAg+/-, Cdh11+/-;TAg+/-, and Cdh11-/-;TAg+/-, on a mixed 129/C57Bl-6 background. This evidence concerns the gene CDH11 and retinoblastoma.