This gene was lost in 58% of 71 retinoblastoma tumors, and its expression showed gradual loss in tumors of the murine retinoblastoma model (TAg-RB) induced by simian virus 40 large T-Antigen (TAg) expression [16], with some advanced tumors (3 of 8) showing loss of Cdh11. Thus, we proposed that Cdh11 acts as a tumor suppressor gene in retinoblastoma. This evidence concerns the gene RB1 and retinoblastoma.