NEGR1 and obesity due to melanocortin 4 receptor deficiency: Not surprisingly, we confirmed the strongest effects (odds ratio for the obesity risk effect alleles of ∼1.4) reported for children and adolescents near FTO, MC4R and TMEM18[12] but also found support for variants near NEGR1, SEC16B, BDNF and BCDIN3D. Thus, one may speculate, that the genetic architecture in the paediatric extremely obese is in part similar to the BMI findings based mainly on adults from large population-based assessments (e.g. [13], [14]).