Thus, we demonstrate that the currently known major common variants related to obesity overlap to a substantial degree between children and adults confirming previous observations for FTO, MC4R, TMEM18, NEGR1[2], [6], [14] and extending this observation to SEC16B, BDNF and BCDIN3D; [13], [14]. The gene discussed is SEC16B; the disease is obesity due to melanocortin 4 receptor deficiency.