We found that in the B16 melanoma and the H22 hepatocarcinoma, the infiltration of CD4+ T-cells, CD8+ T-cells, CD19+ B-cells and NK1.1+ NK-cells were significantly lower in tumors containing the RBP-J deficient DCs than in the tumors containing the control SPDCs (Fig. 3A). The gene discussed is CD19; the disease is melanoma.