Demedts and colleagues identified CCR6 expression on dendritic cells and elevated CCL20 levels in sputum samples from COPD patients suggesting a potential interaction between dendritic cell CCR6 and epithelial CCL20 expression as a potential mechanism explaining the enhanced Langerhans cell numbers seen in COPD patients in their study [3]. Here, CCR6 is linked to chronic obstructive pulmonary disease.