The reference GL8 Env (ABSN) conferred low sensitivity to anti-CD134 (Fig. 7A, 50.9% infection at 2 μg/ml) and high sensitivity to sCD134 (Fig. 7B, 18.4% infection at 2 μg/ml) while in contrast, the B14 Env displayed the reverse phenotype, an enhanced sensitivity to anti-CD134 (Fig. 7A, 19.5% infection at 2 μg/ml) and reduced sensitivity to sCD134 (Fig. 7B, 78.2% infection at 2 μg/ml). The gene discussed is TNFRSF4; the disease is infection.