Various mRNA microarray or differential display studies in human postmortem tissue [15], Mecp2-mutant mice [9,19-22,30], patient fibroblast [18], lymphoblastoid [16,18] and lymphocyte cells [17], and neuroblastoma (SH-SY5Y) cells in which MECP2 has been knocked down [30], have revealed that MeCP2 transcriptionally controls a wide range of functionally distinct genes. Here, MECP2 is linked to neuroblastoma.