A long-term research on the biology of heparanase led to the cloning of a single gene encoding a HS-degrading endoglycosidase (heparanase) which plays important roles in cancer metastasis, angiogenesis and inflammation [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]. This evidence concerns the gene HPSE and cancer.