LAMB2 and lung adenocarcinoma: For example, the CD151 tetraspanin interacts with membrane proteins including the laminin-binding integrin α3β1; when lung adenocarcinoma cells were cultured on laminin-511 and then treated with CD151 siRNA, abnormal membrane protrusions on laminin-511 were apparent and tyrosine phosphorylation dependent signalling was reduced [47].