To evaluate the true expression pattern of TGFBI and SOX4 in GBM and normal brain tissues, we performed quantitative RT-PCR on a panel of 19 individual brain tumor samples and 9 individual normal brain tissues and showed that TGFBI and SOX4 RNA expression are significantly higher (P values of 3.18E-03 and 2.01E-03 respectively, T-test, two-tailed distribution, unequal variance) in GBM tissues compared to normal brain tissues (Figure 4). The gene discussed is TGFBI; the disease is brain neoplasm.