To confirm differential gene expression in individual samples, we randomly picked two up-regulated genes, FOXM1 (forkhead box M1) and CHI3L1 (chitinase 3-like 1), and two down regulated genes, NRGN (neurogranin) and L1CAM (L1 cell adhesion molecule), and evaluated them in a panel of 19 individual brain tumor samples and 9 individual normal brain tissues. The gene discussed is L1CAM; the disease is brain neoplasm.