More recently, its expression has been detected in thymic epithelial cells,[13] various malignant cells,[14–16] and in peripheral blood monocytes, activated by IL-10.[17] HLA-G is known to inhibit the cytotoxic activity of T lymphocytes and natural killer cells (NK),[18, 19] which are essential effector cells in a melanocyte attack.[20] The purpose of the present study is to examine HLA-G expression in the lesional skin of vitiligo patients and in the skin of healthy controls. This evidence concerns the gene HLA-G and vitiligo.