A similar role can be hypothesized for androgens and their receptors, especially in obese females with upper body obesity who exhibit insulin resistance, hyperandrogenemia, hyperinsulinemia, altered gonadotrophin and insulin-like growth factor binding proteins (IGFBPs), increased leptin levels and altered neuro-regulation of hypothalamic-pituitary-gonadal axis[10] [See arrow-2 of Figure 3]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.