In active vitiligo patients an increased oxidative stress of the entire epidermal compartment has been demonstrated.[19] In particular, catalase activity, reduced glutathione, and Vitamin E levels decreased[20] and this imbalance of antioxidants was associated with hyperproduction of ROS.[21] For the first time, in 2004 a report concerning the assessment of oxidative DNA damage in vitiligo patients was published, showing of the quantity of DNA breakage in mononuclear leukocytes of vitiligo patients being comparatively higher.[9]. The gene discussed is CAT; the disease is vitiligo.