There was no evidence for a trans-generational MTHFR mother–child interaction (p = 0.46; crude model, data not shown) and no support was found for a combined effect of genetic and dietary/supplementary risk factors of folate deficiency (High-risk folate deficiency score: OR = 0.95, 95%CI: [0.78;1.15]). This evidence concerns the gene MTHFR and folate deficiency.