Benny and colleagues demonstrated the delivery of two endogenous anti-angiogenic inhibitors, hemopexin (PEX) and a fragment of platelet factor 4 (PF-4) (PF-4/CTF), in vitro and in vivo for human glioma therapy using PLGA microspheres, with glioma growth inhibition observed. This evidence concerns the gene PF4 and central nervous system cancer.