A statistically significant (p < 0.001) increase in the expression of VEGF-A, b-FGF, and eNOS in IUGR placentas was observed in cytotrophoblast, syncytiotrophoblast, extravillous trophoblast, vascular smooth muscle, and villous stromal and endothelial cells compared with normal term pregnancy placentas. The gene discussed is NOS3; the disease is fetal growth restriction.