Since CXCR5 is expressed by PCa cells but not by normal prostate cells, our findings also suggest that CXCL13-CXCR5 interaction regulate ERK1/2 phosphorylation in PCa (LNCaP and PC3) cells, but not in normal prostatic epithelial (RWPE) cells. This evidence concerns the gene CXCL13 and posterior cortical atrophy.