Patients with hyperbilirubinemia had markedly worse survival than those with normobilirubinemia (Figure 1), and had a worse WHO functional class (P = 0.003), higher mRAP (p < 0.001), higher BNP (p = 0.004), and a larger Doppler RV index (p = 0.041). Here, NPPB is linked to Hyperbilirubinemia.