Also αvβ5 integrin interacts with the receptor for urokinase-type plasminogen activator (uPAR or CD87), which in response to ureteral obstruction was significantly upregulated [85], a finding consistent with the fact that obstructed kidneys from uPAR-/-mice showed lower leukocytes and macrophages recruitment in the interstitium than WT mice [85]. Here, PLAUR is linked to Ureteral obstruction.