AURKA and grade III prostatic intraepithelial neoplasia: A role for the centrosomes in the early process of aneuploidy development has been shown by Pihan et al., reporting centrosome defects occurring in carcinoma in situ of prostate, breast and uterine cervical cancers.[8] The mitotic kinase Aurora kinase A (AURKA) is known to be localized to the centrosome[9] and is reported to induce centrosome abnormalities and aneuploidy in human cell lines.[10] Aurora kinase B (AURKB) is also thought to be involved in the development of chromosomal instability.