Insulin-like growth factor-binding protein 7, also known as IGFBP-rP1 and MAC25, can inhibit the proliferation of cancer cells, and its expression is downregulated in certain cancers (Burger et al, 1998; Landberg et al, 2001; Mutaguchi et al, 2003; Sato et al, 2007; Lin et al, 2008; Wajapeyee et al, 2008). Here, IGFBP7 is linked to cancer.