The pathway of the CIN avenue (also referred to as LOH pathway) involves inactivation through genetic and/or epigenetic mechanisms, or loss, or mutation of the suppressor APC gene in chromosome 5q (about 85% of all human colon cancers) whereas the pathway of the MSI avenue involves mutation or epigenetic inactivation of the mis-match repair suppressor genes (about 15% of all colon cancers). The gene discussed is APC; the disease is colonic neoplasm.