In fact, Breivik and Gaudernack [20] showed that in human colon cancer, either methylating carcinogens or hyper-methylation at CpG islands would lead to G/T mismatch which in turn leads to Mis-match Repair (MMR) gene deficiency or epigenetic silencing of the MMR genes and hence MSI (Micro-satellite Instability); alternatively, either hypo-methylation, or bulky-adduct forming (BAF) carcinogens such as alkylating agents, UV radiation and oxygen species promote chromosomal rearrangement via activation of mitotic check points (MCP), thus promoting CIN (Chromosomal Instability). This evidence concerns the gene MRC1 and colonic neoplasm.