LMNA and laminopathy: One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C. Mutations in LMNA are associated with more than 13 different tissue-specific diseases, collectively termed laminopathies, which include muscular dystrophies, cardiomyopathies, and more recently, a series of progeroid diseases that resemble some aspects of premature aging (for review, see Cohen et al.)[5].