Deregulation of cyclin-dependent kinases and abnormal patterns of E2F1 regulation have also been linked with Alzheimer's disease [204], [205], [206], [207], [208], neurodegeneration [205], [207], [209], [210], [211], [212], [213], [214], [215], and neuronal apoptosis [216], [217], [218], [219], [220]. This evidence concerns the gene E2F1 and early-onset autosomal dominant Alzheimer disease.