LRP1B and Alzheimer disease: Poduslo et al. have suggested that if the decreased production of Abeta42 in successful aging is due to the haplotypes they describe, then LRP1B may be a new target for treatment of AD [608], [617], Taken together these results indicate that integrative bioinformatics analytic approaches will be needed to elicit the interactome of LRPs and their role in AD.