Two of these genes, CSF1 (colony stimulating factor 1 (macrophage)) and HBEGF (heparin-binding EGF-like growth factor) appear to be conspicuous mediators of cytokine and growth factor signalling as Figure 9 illustrates (we obtained this network using Pathway Studio[569] as described in the previous section), and CSF1 and HBEGF seems to be increasing with AD severity. This evidence concerns the gene CSF1 and Alzheimer disease.