Being aware of the existing interest on Wnt Signalling and AD, we went back to the list of genes present in our (alpha,beta)-k-feature set signature and we identified others that can also be linked to Wnt signalling, like CSNK1G3, CSNK2A2, FRAT1[76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], FZD5[89], [90], [91], MDFIC, PIAS4, SOX2 [92], [93], [94], [95], [96], TCF7L1/TCF3[89], [97], [98], TCF7L2/TCF4[99], [100], [101], [102], [103], [104], [105], [106], and TLE3[106], [107], [108], [109]. The gene discussed is PIAS4; the disease is Alzheimer disease.