Although no connection has been found between NRXN1 and AD yet, this gene has been implicated in autism [570], [571], [572], [573], [574], [575], [576], schizophrenia [577], [578], [579], [580], [581], nicotine and alcoholism dependence [582], [583], [584], and mental retardation [585]. This evidence concerns the gene NRXN1 and Alzheimer disease.