Our identification of EGR1/KROX-24 and PAX-6 as upregulated with AD progression, and the identification of motif V$KROX_Q6, V$MAZ_Q6, V$E2F1_Q6_01, V$E2F1_Q3_01 as enriched in our signature were two contributing factors that motivated us to explore any further similarities that we could find. Here, PAX6 is linked to Alzheimer disease.