In the rat brain, NTSR3/Sortilin as well as TREK-1 are highly expressed in cerebral structures involved in the pathophysiology of depression [13], such as prefrontal and cingulate cortice, amygdala, hippocampus, nucleus accumbens, dorsal raphe, and hypothalamus [7],[8]. The gene discussed is KCNK2; the disease is depressive disorder.