To this end, perturbations of the folding free energy landscapes of a set of five ALS-variants of SOD1 with survival times of less than 3 years [26], [27] were mapped; the wild-type-like variants [28], A4V, L38V, G93A and L106V, and the metal-binding variant, S134N. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.