Also the expression of Bcl-2 and Bax proteins, evaluated by immunohistochemical staining in specimens from 110 patients with oral squamous cell carcinoma (OSCC) showed that the 5-year survival rate was significantly higher in patients with a ratio of Bcl-2/Bax ≤ 1 as compared to those with Bcl-2/Bax > 1 [34]. This evidence concerns the gene BCL2 and oral cavity squamous cell carcinoma.