PGAM1 and neoplasm: As shown in Fig. 5B, tail intravenous injections of PGAM-shRNA-a resulted in more than 75% suppression of PGAM1 in tumor-bearing mice, whilst no obvious difference could be observed regarding the expression level of PGAM1 in the control mice either treated with Lipofectamine 2000 or NC-shRNA, relative to injection with PBS.