Furthermore, in the presence of GAPDH, Nm23-H1 could phosphorylate PGAM1 and inhibit PGAM1 activity resulting in suppression of glycolysis and inducing growth arrest in various cancer cells, including glioblastoma cell line Tx3095, small lung cancer cell line GLC4, beast carcinoma cell lines MCF-7 and MDA-MB-453, etc [13]. This evidence concerns the gene NME1 and cancer.