IHC staining, performed on 10 human seminomas, showed no uPA reactivity in the autologous normal testis surrounding the tumor (panel A, figure 3), while an intense uPA immunoreactivity was evidenced (score 2+/3+) in 3 out of 10 (30%) samples (p = 0.105) (panel C, figure 3). Here, PLAU is linked to seminoma.