ADRB1 and tricuspid valve insufficiency: One recent study measured with a tricuspid regurgitation jet of >2.5 m/sec, showed evidence of association on genes of the TGF-beta superfamily, including activin A receptor type II–like 1 (ACVRL1), bone morphogenetic protein receptor 2 (BMPR2), and BMP6, the beta-1 adrenergic receptor (ADRB1).115