A recent study suggested that polymorphisms in the beta2-adrenergic receptors (ADRB2) and adenylate cyclase 6 (ADCY6) may influence SCD severity through the signalling pathway of RBC adhesion to laminin.121 In this study, they found that SNP rs1042713 in ADRB2 and SNP rs3730070 of ADCY6 polymorphisms were associated with elevated adhesion (P = 0.037 and P = 0.0002 respectively). This evidence concerns the gene ADRB2 and Schnyder corneal dystrophy.