CYBB and malaria: Among them a prominent signal on Chromosome 10p15 obtained with malaria fever episodes135 and on Chromosome 5q31–q33.136 Several human gene SNPs have been described to be linked with the severity of the malaria such as: CYBB gene,137 the gp91 phox subunit of the NADPH oxidase,137 the TNF-enhancer and gene for FcgammaRIIa,134 IL12B136 as well as the haptoglobin haplotype polymorphism.138 These studies show a relationship between red blood cell efficiency and the severity of the malaria as observed in the SCA.