Other studies attempted to associate stroke risk with SNPs in the angiotensinogen (AGT), cystathionine-beta-synthase (CBS), cholesteryl ester transfer protein (CETP), integrin, beta 3 (ITGB3), apolipoprotein C-III (APOC3), 5,10-methylenetetrahydrofolate reductase (MTHFR), serpin peptidase inhibitor, clade E (PAI1), intercellular adhesion molecule 1 (ICAM1) and thrombospondin receptor (CD36) genes,64,69 but due to the few patients studied, replication of these results in a larger patient sample is necessary. This evidence concerns the gene ITGB3 and stroke disorder.