IGF1R and autosomal dominant cerebellar ataxia: A recent study on the CSSCD cohort, showed significant associations with SNPs in insulin-like growth factor 1 receptor (IGF1R) and genes of the TGF-beta/BMP pathway (BMP6, TGFBR3, bone morphogenetic protein receptor, type IA (BMPR1A), SMAD6 and SMAD3) suggesting that both could play important roles in immune function in SCA and their polymorphisms may help identify a “bacteremia-prone” phenotype.108