PPA is most commonly associated with the non-Alzheimer FTLD pathologies, i.e. tau-positive or TDP-43 positive inclusions, but LPA in particular can be associated with Alzheimer's disease pathology i.e. amyloid plaques and tau-positive neurofibrillary tangles [5]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.