Our real-time PCR finding is consistent with recent reports by Bond et al. and Hong et al [6,8] that the MDM2 309GG genotype carriers had significantly higher MDM2 expression in NPC tissues than the TT and TG genotype carriers, suggesting the variant MDM2 genotype may cause attenuated TP53 function. This evidence concerns the gene TP53 and nasopharyngeal carcinoma.