TP53 and nasopharyngeal carcinoma: Moreover, Logistic regression analysis showed that subjects with TP53 Pro allele significant increased risk of NPC compared with subjects carrying the Arg allele (OR for the Arg/Pro genotype, 1.43; 95%CI, 1.22-2.13; OR for the Pro/Pro genotype, 2.22; 95%CI, 1.58-3.10; Ptrend < 0.001), suggesting that the Pro allele is the high-risk allele.