We therefore speculated that EIF4G1 may play a role in NPC by inhibiting the functions of PDCD4. In the present study, we found that the reduction of endogenous EIF4G1 protein expression increased the expression levels of PDCD4. This result supports the potential involvement of EIF4G1 in regulating PDCD4 expression. Here, PDCD4 is linked to nasopharyngeal carcinoma.