EIF4G1 and nasopharyngeal carcinoma: Among the 6 NPC cell lines, 5-8F cells had the highest expression levels of EIF4G1 (Figure 1A); this cell line is also highly tumorigenic and metastatic [17,18], suggesting of 5-8F cells as a good model system for studying the functions of endogenous EIF4G1 by loss-of-function approach.