One study by Bardia and colleagues [7] looked into the risk of developing postmenopausal breast cancer stratified by estrogen receptor (ER) and progesterone receptor (PR) subtypes and reported that an increase in weight at age 12 years was associated with a decrease in adult breast cancer risk, with the most pronounced effects exhibited by ER-positive/PR-negative tumours. Here, ESR1 is linked to breast carcinoma.