To determine the effect of APC on the procoagulant response in severe influenza, we infected mice with a lethal dose of influenza A virus and initiated rm-APC (or buffer control) treatment 24 hours after infection; subsequently, we determined the levels of TATc and FDP in lung homogenates (Figure 1A, B) and plasma (Figure 1C, D) at 48 and 96 hours after infection. Here, AMACR is linked to influenza.