For example, Sakai et al. demonstrated that constitutive expression of SOCS3 affected the IFN-α sensitivity of chronic myelogenous leukemia (CML) cell lines and blast cells from patients in CML blast crisis [39], while Brender et al. demonstrated that SOCS3 protected T cell lymphoma cells against growth inhibition by IFN-α [40]. Here, SOCS3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.