TNF and infection: This serious infection rate ratio of 1.44 (0.86 to 2.42) is within the lower limit of the 95% CI for the pooled odds ratio reported in the meta-analysis of serious infections in anti-TNF controlled trials by Bongartz (pooled Mantel-Haenszel OR 2.0 (1.3 to 3.1)) [3] and similar to the fixed combined OR of 1.35 (0.79 to 2.32) reported by Saillot [23].