A cohort study by Gimotty et al. on 396 thin melanomas (tumor thickness ≤1 mm) with at least 10 years follow-up, showed mitotic count ≥1 per mm2 and Ki-67 expression in ≥20% of tumor cell nuclei to be independent prognostic factors of metastases [9]. The gene discussed is MKI67; the disease is neoplasm.