IGHG3 and malaria: Taken together, these data show that although pre-existing IgG/IgG3 antibodies to antigens representing the major dimorphic types of MSP-2 are strongly associated with a reduced incidence of clinical malaria in the majority of children (8), a minority still develop disease despite having had not only high level antibodies, but also antibodies to allele-specific epitopes within those antigens.