NPPB and myocardial ischemia: Previous studies have reported that B-type natriuretic peptide (BNP), synthesized as pre-proBNP mainly in the ventricular myocardium and secreted in response to ventricular volume and pressure overload, has close relation with angiographic severity and could be a potential biomarker for myocardial ischemia even in patients with preserved LV systolic function [1–4].