Comparing cell surface markers expressed on tumor cell lines susceptible to γδ T cell lysis with those expressed by resistant tumor cell lines suggested that a structure related to the mitochondrial ATP-synthase molecule may be an antigen [105] The F1-ATPase bound directly to the Vγ2Vδ2 TCR, as shown by surface plasmon resonance, and binding induced IFN-γ and TNF-α release from clones. Here, TNF is linked to neoplasm.