Given the role that AEBP1 plays in LPS signaling in macrophages, and given AEBP1 role in inducing macrophage proinflammatory responsiveness [265] via promoting NF-κB activity in macrophages [266], it is conceivable that AEBP1−/− mice may be resistant to LPS-induced septic shock and Gram-negative bacterial infection-induced atherosclerosis. This evidence concerns the gene AEBP1 and gram-negative bacterial infections.