THBS2 and endometrial cancer: Other genes inactivated by promoter hypermethylation in endometrial cancer include PgR [69], the cell cycle control genes 14-3-3 sigma [70], homeobox gene HOXA11, thrombospondin-2 gene (THBS2) [71], paternally expressed gene 3 (PEG3) [72], as well as the detoxifying enzyme glutathione S-transferase P1 (GSTP1) [73].