4 hours after stroke onset, lesion volume was larger in the delayed rt-PA group (135.8 ± 22 mm3) than in the deco group (80.2 ± 14 mm3; p < 0.05), the early G-CSF group (65.1 ± 17 mm3; p < 0.005), and early rt-PA (57 ± 17 mm3; p < 0.005). This evidence concerns the gene CSF3 and Stroke.