However, other CAD risk variants located telomeric to the core risk haplotype region such as rs7044859 and rs496892 showed substantially larger effects and stronger associations with ANRIL expression (P<10−60 for each SNP), and were also significantly associated with CDKN2A and CDKN2B expression (P<10−4 for each SNP). This evidence concerns the gene CDKN2B and coronary artery disorder.