We have shown that multiple sites in the 9p21 region independently influence CDKN2A, CDKN2B and ANRIL expression, and demonstrated that SNPs associated with diseases including CAD, diabetes, and cancers are all highly associated with ANRIL expression, suggesting that modulation of ANRIL expression may mediate disease susceptibility. Here, CDKN2B-AS1 is linked to coronary artery disorder.