CDKN2B-AS1 and coronary artery disorder: Associations for these SNPs remained significant after adjusting for the effect of the lead CAD SNPs within the core risk haplotype region (rs10757274, rs2383206, rs10757278 and rs1333049) [35], but SNPs within the core risk haplotype were no longer significantly associated with ANRIL expression after adjusting for the effect of SNPs at the distal locus (rs10965215 and rs564398).