CHEK2 and ovarian neoplasm: Although our data support that two SNPs in the CHEK2 gene are associated with the risk of developing invasive serous ovarian cancer, it is of note that one prior study in Poland did not find evidence for an association between invasive epithelial ovarian cancer of any histologic subtype and three founder alleles in the CHEK2 gene but did find evidence for an association with ovarian tumors of low malignant potential and the CHEK2 I157T missense variant {Szymanska-Pasternak, 2006 #447}.